Currently, the major treatment options for Hemophilia A are Factor Replacement Concentrates, the source of which is either recombinant DNA technology or Human plasma-derive, and Bypassing agents. Moreover, this is an off-label treatment option, wherein Desmopressin Acetate (DDAVP) and Adjunctive therapies are also available for the management of Hemophilia A.
Companies like BioMarin Pharmaceutical, Novo Nordisk, Sanofi, Pfizer, Sangamo Therapeutics, Spark Therapeutics, and others are coming up with novel therapeutic approaches that can entirely change the treatment landscape of Hemophilia A. If launched, these emerging potential candidates could pose an adverse threat to current hemophilia A pharmaceutical giants by means of their potential to transform the standard of care for hemophilia A patients.
“Hemophilia A Pipeline Insight, 2023” report by DelveInsight outlines a comprehensive assessment of the present clinical/non-clinical development activities and growth prospects across the Hemophilia A Market.
The Hemophilia A Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers, acquisition, funding, designations, and other product-related details.
Hemophilia A Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the emerging therapies for the treatment of Hemophilia A and the aggregate therapies developed by major pharma companies.
It accesses the different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of clinical development.
It outlines the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
The report evaluates the drugs that are under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
It navigates the major collaborations (company-company collaborations and company-academia collaborations), licensing agreements, financing details, data presentation by the pharma giants, and regulatory approval in the Hemophilia A market.
The report is built using data and information traced from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.
Analysis of Emerging Therapies by Phases
The report covers the emerging products under different phases of clinical development like –
Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I)
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates
Route of Administration
Hemophilia A pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
Oral
Parenteral
Intravitreal
Subretinal
Topical
Molecule Type
Products have been categorized under various Molecule types, such as
Monoclonal Antibody
Peptides
Polymer
Small molecule
Gene therapy
Mechanism of Action of the Emerging Pipeline Therapies
Factor VIII replacements
Blood coagulation factor stimulants
Factor X stimulants
Factor VIIa stimulants
Gene transference
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Hemophilia A Therapeutics Landscape
The Hemophilia A therapeutic market dynamic is anticipated to evolve immensely in the coming years owing to the rise in the prevalent population of Hemophilia A, the expected entry of premium price assets such as gene therapy, siRNA, and bispecific antibodies, and the expected readily uptake of recently approved therapies.
There are approx. 35+ key companies developing therapies for Hemophilia A. Currently, Novo Nordisk is leading the therapeutics market with its Hemophilia A drug candidates in the most advanced stage of clinical development.
The Leading Companies in the Hemophilia A Therapeutics Market Include:
Alnylam Pharmaceuticals, ASC Therapeutics, Ascension, BioMarin Pharmaceutical, Catalyst Biosciences, Centessa Pharmaceuticals, Chia Tai Tianqing Pharmaceutical Group, Chugai Pharmaceuticals, Dimension Therapeutics, Expression Therapeutics, Hoffmann-La Roche, Intellia Therapeutics, Kymab, Novo Nordisk, Pfizer, Poseida Therapeutics, Regeneron Pharmaceuticals, Sanofi Genzyme, Spark Therapeutics, Staidson Beijing BioPharmaceuticals, and many others.
Hemophilia A Drugs Covered in the Report Include:
ASC618: ASC Therapeutics
BIVV001: Sanofi/Sobi
Concizumab: Novo Nordisk
ET3 lentiviral gene therapy: Expression Therapeutics
Fitusiran: Sanofi/Alnylam Pharmaceuticals
Giroctocogene fitelparvovec (SB-525/PF-07055480): Pfizer/Sangamo Therapeutics
Marstacimab: Pfizer
Marzeptacog alfa: Catalyst Biosciences
Mim8: Nono Nordisk
NXT007: Chugai Pharmaceuticals
PF-07055480: Pfizer
RG6357 (SPK-8011), RG6358 (SPK-8016): Roche/Spark Therapeutics
SelectAte: Ascension
STSP-0601: Staidson (Beijing) Biopharmaceuticals
TQG 203: Chia Tai Tianqing
Valoctocogene Roxaparvovec (BMN 270): BioMarin Pharmaceutical
Valrox: BioMarin Pharmaceutical
And Many More
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Table of Content (TOC)
1. Report Introduction
2. Executive Summary
3. Hemophilia A Current Treatment Patterns
4. Hemophilia A – DelveInsight’s Analytical Perspective
5. Therapeutic Assessment
6. Hemophilia A Late Stage Products (Phase-III)
7. Hemophilia A Mid-Stage Products (Phase-II)
8. Hemophilia A Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Hemophilia A Discontinued Products
13. Hemophilia A Product Profiles
14. Key Companies in the Hemophilia A Market
15. Key Products in the Hemophilia A Therapeutics Segment
16. Dormant and Discontinued Products
17. Hemophilia A Unmet Needs
18. Hemophilia A Future Perspectives
19. Hemophilia A Analyst Review
20. Appendix
21. Report Methodology
*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.
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